Acesulfame-K (Ace-K): Independent Evidence on Cancer Risk & Safety
The unreplicated cancer cohort signal — what it means. Independent human-trial evidence, funding traced, evidence graded.
Pure City Research
Saccharin: Independent Evidence on Safety, Cancer History & ADI
The bladder-cancer scare that was rat-specific — resolved. Independent human-trial evidence, funding traced, evidence graded.
Sucralose: Independent Evidence on Gut Microbiome, Glucose & Safety
Gut microbiome shifts and glycemic effects in human RCTs. Independent human-trial evidence, funding traced, evidence graded.
Aspartame: Independent Evidence on Cancer Risk, ADI & Safety
IARC 2B, NutriNet-Santé, JECFA ADI — what the evidence shows. Independent human-trial evidence, funding traced, evidence graded.
Monk Fruit (Luo Han Guo): Forms, Mogroside Grades & Independent Evidence
Mogroside V grades, forms, and the thin human evidence. Independent human-trial evidence, funding traced, evidence graded.
Stevia: Forms, Grades & Independent Evidence on Glucose, Blood Pressure & Safety
Stevioside vs Reb A vs Reb M — which form actually works. Independent human-trial evidence, funding traced, evidence graded.
Saffron for Depression: What a New 34-Trial Meta-Analysis Says About the ‘Natural SSRI’ Claim
Key takeaways The newest and largest evidence base — a 34-trial, 1,769-person GRADE meta-analysis (Mahmoudi et al., 2026, Nutrition & Neuroscience) — found saffron improves self-reported depression (BDI) and anxiety (BAI) scores with moderate-certainty evidence, but found no significant effect on clinician-rated depression (HDRS), clinician-rated anxiety (HARS), or general mood (POMS). The “natural SSRI” framing … Read more
Garlic for Blood Pressure: The Meta-Analyses That Actually Back This Up
Key takeaways Strongest evidence: garlic supplementation modestly lowers blood pressure, roughly 3.7–4.4 mmHg systolic and 3.1–3.4 mmHg diastolic in non-industry-funded meta-analyses, concentrated in people who already have elevated blood pressure (Tang et al. 2025; Wang et al. 2015). Industry-linked meta-analyses from the same lead author who ran a Wakunaga-funded Aged Garlic Extract trial report larger … Read more
NMN Supplements: What the FDA Flip-Flop Means and What the Human Data Actually Shows
Key takeaways NMN reliably raises blood NAD+ in every published human trial, at doses from 100 mg to 1,250 mg/day — that part is well replicated (Yoshino et al. 2021, Science, Yi et al. 2022, GeroScience). What NAD+ elevation actually does for a healthy adult’s function is still thin: a 2024 systematic review of 10 … Read more
Probiotics: Why the Strain on the Label Matters More Than the CFU Count
Key takeaways Strongest evidence: Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG ATCC 53103 reduce antibiotic-associated diarrhea risk, and multi-strain probiotic mixtures reduce C. difficile-associated diarrhea in people taking antibiotics (Cochrane 2017). “Probiotics help gut health” as a category claim is not supported — EFSA rejected essentially every general immune and digestive-health claim submitted for … Read more