Heart & Cardiovascular

Evidence-graded research on heart and cardiovascular health — what trials and regulators show about omega-3, CoQ10 and other supplements, conflicts disclosed.

Garlic for Blood Pressure: The Meta-Analyses That Actually Back This Up

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Key takeaways Strongest evidence: garlic supplementation modestly lowers blood pressure, roughly 3.7–4.4 mmHg systolic and 3.1–3.4 mmHg diastolic in non-industry-funded meta-analyses, concentrated in people who already have elevated blood pressure (Tang et al. 2025; Wang et al. 2015). Industry-linked meta-analyses from the same lead author who ran a Wakunaga-funded Aged Garlic Extract trial report larger … Read more

Berberine vs. Ozempic Claims: What the Blood Sugar Data Really Shows

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Key takeaways Strongest evidence: berberine 0.9–1.5 g/day lowers fasting glucose, post-meal glucose, and LDL/triglycerides in people with type 2 diabetes or metabolic syndrome, with effect sizes comparable to low-dose oral diabetes drugs in short trials (Wang et al. 2024 meta-analysis, Liu et al. 2025 meta-analysis). “Nature’s Ozempic” is not supported by the data — GLP-1 … Read more

Heart Disease: Supplements That Work vs Popular Ones With No Evidence

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Key takeaways Soluble fiber has the strongest LDL-lowering evidence: a meta-analysis of 181 RCTs found each 5 g/day increment reduced LDL-C by 8.28 mg/dL and total cholesterol by 10.82 mg/dL, with the review authors reporting no funding. Plant sterols/stanols reliably lower LDL-C (a 59-trial meta-analysis found a 0.31 mmol/L reduction), but a key older meta-analysis … Read more

Heart Disease: Prevention and Management — The Complete Evidence-Based Guide

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Key takeaways WHO reports cardiovascular disease caused an estimated 19.8 million deaths in 2022 — about 32% of all global deaths — with heart attack and stroke accounting for 85% of that toll (WHO CVD fact sheet). A reanalysis of the PREDIMED trial (7,447 high-risk adults) found a Mediterranean diet supplemented with olive oil or … Read more

Cancer: Supplements That Work vs Popular Ones With No Evidence

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Key takeaways The strongest ingredient-level evidence is for food, not pills: a dose-response meta-analysis found every 10 g/day increase in dietary fiber was associated with a 10% lower colorectal cancer risk (RR 0.90), and three daily servings of whole grains were linked to a 17% lower risk (RR 0.83). A 47-trial meta-analysis (commissioned by WHO’s … Read more

Cancer: Prevention and Management — The Complete Evidence-Based Guide

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Key takeaways WHO states about 38% of cancers can currently be prevented by avoiding known risk factors and applying evidence-based prevention strategies — meaningful risk reduction, not a guarantee (WHO cancer fact sheet). IARC classifies alcoholic beverages and processed meat as carcinogenic to humans, and red meat as probably carcinogenic — mainly for colorectal cancer … Read more

CoQ10: Ubiquinone vs Ubiquinol, Heart Health, and Statin Muscle Pain

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Key takeaways Best-supported use: statin-associated muscle pain — a meta-analysis of 12 RCTs (575 patients) found CoQ10 (100–200 mg/day) reduced statin-induced myalgia severity by ~30% (Qu et al., J Am Heart Assoc 2018). Moderate evidence: heart failure — the Q-SYMBIO trial (420 patients, 2 years) found 300 mg/day reduced major cardiovascular events by 43% in … Read more