Health concerns

Health Concerns — Evidence-Based Research

Prevention and management guides for major health conditions, paired with honest supplement evidence for each one. We organize research around what you are actually trying to understand — and separate what the studies support from what only marketing claims.

By condition

Explore by health concern

Fourteen core topic areas, each with a category page collecting the research currently available. Coverage varies by topic and is being expanded.

✚
Cancer
Risk reduction, lifestyle evidence, and supplement claims examined against the trial data.
♥
Heart & Cardiovascular
Cholesterol, lipids, omega-3 and CoQ10 — what protects the heart and what doesn't.
◐
Diabetes & Blood Sugar
Insulin sensitivity, glucose control, and the metabolic-health evidence base.
≈
Asthma & Respiratory
Triggers, management, and the supplement claims tested against respiratory outcomes.
❋
Eczema & Skin
Barrier care, flare management, and which nutrients the evidence actually supports.
⌒
Blood Pressure
Minerals, vascular function, and lifestyle levers for hypertension.
◍
Gut & Digestion
Microbiome, bloating, regularity, and absorption — grounded in the research.
☾
Sleep
Falling asleep, staying asleep, and circadian rhythm — behavior first, supplements second.
◇
Stress, Anxiety & Depression
Adaptogens, amino acids, and mood support — and the evidence behind each.
↘
Fat Loss & Metabolism
What actually moves the needle for weight and metabolic health (and what doesn't).

Coverage in progress — this category does not yet include both article formats.
✦
Energy & Focus
Fatigue, cognition, and mitochondrial support — evidence vs hype.

Coverage in progress — this category does not yet include both article formats.
⬢
Muscle Building
Protein, creatine, and hypertrophy — the strength and performance evidence.

Coverage in progress — this category does not yet include both article formats.
❂
Neurology & Brain Health
Narcolepsy, cognition, neurodegenerative risk — the neurological evidence.

Coverage in progress — this category does not yet include both article formats.
◈
Autoimmune & Inflammatory
Rheumatoid arthritis and immune-mediated inflammation evidence.

Coverage in progress — this category does not yet include both article formats.
How each condition is covered

Two article formats, where available

For several conditions, we publish two complementary formats: a prevention and management guide, and a focused supplement-evidence review. Not every category currently has both formats.

1
Full prevention & management guide
The complete picture for a condition — risk factors, prevention strategies, day-to-day management, and the lifestyle and clinical evidence that underpins each recommendation.
  • What raises and lowers risk
  • Prevention and management strategies
  • Evidence graded from Strong to Insufficient
2
Supplements that work vs. no evidence
A focused verdict on the supplements marketed for the condition — which ones have real supporting evidence, and which are sold on claims the studies don't back up.
  • Supplements with genuine supporting evidence
  • Popular options with little or no evidence
  • Interaction and safety flags called out
Recent additions

Recently published or updated articles

Recently published or updated guides across our health-concern categories.

Heart health: what the evidence supports
A refreshed look at diet, movement, and the supplements that do — and don't — move cardiovascular outcomes.
Browse current articles
Sleep: behavior before supplements
Why the strongest gains come from habits and timing, and where melatonin genuinely helps.
Browse current articles
Stress & mood: sorting signal from hype
Adaptogens and amino acids weighed against the trial data, with interaction risks flagged.
Browse current articles
Our methodology

Guides prioritize original research, evidence syntheses, and regulatory guidance. They are intended to distinguish prevention and management evidence from supplement claims, while reporting study funding and disclosed conflicts where identified.

Read how we research and grade evidence · See our full source list

Check each guide for its visible review date and any dated change notes.