St John’s Wort vs Saffron vs SSRIs for Depression: What Independent Evidence Shows
Key takeaways SSRIs have the only regulator-audited evidence base of the three. An FDA analysis of individual patient data from 232 trials (Stone et al., BMJ 2022) found that about 15% of participants get a large benefit beyond placebo, and the benefit grows with severity. Published trials overstated the effect by about a third (Turner … Read more