Independent research on stress, anxiety and depression — supplement and lifestyle claims graded honestly, with funding and conflicts made transparent.
Key takeaways Best-supported use: acute stress and cognitive performance under high-demand conditions (sleep deprivation, cold exposure, multitasking under noise) — military and lab RCTs show 100–150 mg/kg tyrosine restored working memory and reaction time when depleted by stress (Hase et al., Neurosci Biobehav Rev). Works by replenishing dopamine and norepinephrine precursors that get depleted under … Read more
Key takeaways Strongest evidence: correcting low dietary intake, migraine prevention (300–600 mg daily under medical supervision), and modest blood-pressure reduction — with meta-analyses supporting a systolic drop of ~2 mmHg (Cochrane, Journal of Human Hypertension). For sleep, anxiety, muscle cramps, depression, diabetes, and bone health, evidence is mixed to weak — a systematic review found … Read more
Key takeaways Strongest evidence: modest triglyceride reduction (25–30% with 2–4 g/day EPA+DHA) and reduced cardiovascular events in secondary prevention at prescription doses — FDA has approved icosapent ethyl (EPA-only, 4 g) after the REDUCE-IT trial. For primary prevention of heart disease in the general population, effects are modest at best — a large Cochrane review … Read more
Key takeaways Melatonin is a timing signal, not a sedative — strongest evidence is for jet lag (Cochrane: 8 of 10 trials showed benefit; 0.5–5 mg equally effective, higher doses not better) and delayed sleep-wake phase disorder. For chronic adult insomnia, AASM explicitly recommends against it — the recommendation is graded weak based on small … Read more
