Lamotrigine: Independent Evidence on Epilepsy, Bipolar & Rash
Independent review of lamotrigine for epilepsy and bipolar maintenance: SANAD, Cochrane evidence, serious rash, pregnancy, the pill, the 2021 FDA warning and funding.
Neurology & Brain Health
Topiramate: Independent Evidence on Epilepsy, Migraine & Risks
Topiramate works for seizures and migraine but carries serious pregnancy risks. We trace the funding behind the evidence, side effects and Qsymia.
Vertigo and BPPV: Independent Evidence on Epley, Drugs & Funding
Vertigo and BPPV: what the Epley manoeuvre, rehabilitation and betahistine trials show, how HINTS spots stroke, driving rules, and who funded the evidence.
Tinnitus: Independent Evidence on Causes, CBT, Devices & Cures
Tinnitus is common and usually benign, but some features need urgent checks. We grade CBT, hearing aids, devices and supplements and trace who funded the evidence.
Peripheral Neuropathy: Independent Evidence on Nerve Pain Drugs
Causes, tests and the NICE drug ladder for nerve pain, with supplements graded, foot care in diabetes and who funded the evidence, including gabapentin’s 2004 plea.
Alzheimer’s Disease: Independent Evidence on Tests and Drugs
Alzheimer’s disease diagnosis, blood tests, donepezil, memantine, lecanemab, donanemab, prevention and supplements, graded by who funded the evidence.
Migraine: Independent Evidence on Treatment, CGRP Drugs & Funding
What the evidence shows for migraine attacks and prevention, from triptans to CGRP drugs, plus supplements, medication-overuse headache and who funded the research.
Nortriptyline: Independent Evidence on Depression, Nerve Pain, Smoking & Risks
Independent review of nortriptyline: depression and late-life relapse evidence, off-label smoking cessation, weak nerve-pain data, overdose risk and blood levels.
Pregabalin: Independent Evidence on Pain, Anxiety, Side Effects & Withdrawal
Pregabalin (Lyrica) helps a minority with nerve pain, focal epilepsy or GAD, but misuse, dependence and breathing risks with opioids made it a UK controlled drug.
Duloxetine: Independent Evidence on Depression, Pain, Side Effects & Withdrawal
Duloxetine (Cymbalta) works for depression, anxiety and diabetic nerve pain, but gains are modest and liver, bleeding and withdrawal risks need care.