St John’s Wort: Depression Evidence and Serious Interaction Risks
Key takeaways Strongest evidence: mild-to-moderate depression — a Cochrane review of 29 trials (5,489 patients) found St John’s Wort more effective than placebo and comparable to standard antidepressants for mild-to-moderate depression, with fewer side effects than SSRIs. Not effective for severe depression, bipolar depression, or as an alternative to prescribed SSRIs for confirmed major depressive … Read more