Mirtazapine: Independent Evidence on Depression, Sleep, Weight Gain & Withdrawal
Mirtazapine works for depression, but sedation and weight gain are common. Off-label use for insomnia rests on thin evidence. Who funded the trials?
Stress, Anxiety & Depression
Independent research on stress, anxiety and depression — supplement and lifestyle claims graded honestly, with funding and conflicts made transparent.
Esketamine (Spravato): Independent Evidence on TRD, Side Effects & Risks
Esketamine nasal spray (Spravato) for treatment-resistant depression: what the FDA files, NICE and independent re-analyses show about its benefit, risks and funding.
Duloxetine: Independent Evidence on Depression, Pain, Side Effects & Withdrawal
Duloxetine (Cymbalta) works for depression, anxiety and diabetic nerve pain, but gains are modest and liver, bleeding and withdrawal risks need care.
Diazepam (Valium): Independent Evidence on Anxiety, Side Effects & Withdrawal
Diazepam (Valium) eases acute anxiety, seizures and alcohol withdrawal fast, but carries FDA boxed warnings on opioids and dependence. What independent evidence shows.
Bupropion: Independent Evidence on Depression, Quitting Smoking & Side Effects
Bupropion (Zyban/Wellbutrin): what independent evidence shows for quitting smoking and depression, seizure risk, sexual side effects, and who funds the research.
Amitriptyline: Independent Evidence on Pain, Migraine, IBS, Risks & Withdrawal
Independent review of amitriptyline: ATLANTIS IBS trial, nerve pain, migraine and depression evidence, overdose and anticholinergic risks, and who funded it.
Citalopram: Independent Evidence on Depression, Panic, Side Effects & Withdrawal
Independent review of citalopram for depression and panic: Cipriani 2018 results, QT dose limits for over-65s, side effects, withdrawal and who funded the evidence.
Fluoxetine: Independent Evidence on Depression, OCD, Side Effects & Withdrawal
Independent review of fluoxetine (Prozac): NICE, Cochrane and FDA evidence for depression, young people, OCD and bulimia, plus risks and who funded the trials.
Sertraline: Independent Evidence on Depression, Side Effects & Withdrawal
Sertraline reviewed: what independent trials show for depression, OCD, PTSD and anxiety, plus side effects, interactions, withdrawal and who funded the evidence.
Escitalopram: Independent Evidence on Depression, GAD, Side Effects & Withdrawal
Escitalopram (Cipralex/Lexapro): what independent trials show for depression and anxiety, side effects, QT dose limits, withdrawal, and who funds the evidence.